Antioxidants / Oxidative Stress: the reality for clinical practice

The production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) has long been proposed as leading to random deleterious modification
of macromolecules with an associated progressive development of age associated systemic disease. ROS and RNS formation has been posited as a major contributor to the ageing process. On the contrary, this seminar will
present evidence that superoxide anion (and hydrogen peroxide) and nitric oxide (and peroxynitrite) constitute regulated prooxidant second messenger systems, with specific sub-cellular locales of production and are essential for normal metabolome and physiological function. The resultant consideration has significant implications for clinical practice.

A/Prof Luis Vitteta

Supported by BioCeuticals & Unit of Health Integration, School of Medicine, University of Queensland